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Wednesday, August 19, 2026The Morning Brief →Sign in
IBRNISharesINDEX

iShares Neuroscience and Healthcare ETF

$40.55+1.97% today
244152-WK

The fund will invest at least 80% of its assets in the component securities of its index and in investments that have economic characteristics that are substantially identical to the component securities of its index and may invest up to 20% of its assets in certain futures, options and swap contracts, cash and cash equivalents as well as in securities not included in the index, but which BFA believes will help the fund track the index. It is non-diversified.

Price & daily flows
37.032.327.740.55DAILY NET FLOWAug 19Dec 16Apr 17Aug 19

SOURCE: MARKET TAPE & DAILY CREATION/REDEMPTION RECORDS · 3Y SHOWN · NET +$778K OVER THIS RANGE

The desk’s read

Money keeps arriving — +$2M of net buying over the past month, while the price has returned +27.6% so far this year. At 0.47% a year it is not the cheapest way in — IWM runs the same ground at 0.19%.

COMPOSED FROM THE FUND’S OWN DAILY RECORDS · UPDATED WITH EACH REFRESH

$7931.50Tassets under management
0.47%expense ratio · $47 per $10,000 a year
+$2Mnet flow, trailing month
3Kavg daily volume, 30 days
54holdings
2022listed August 23, 2022 · beta 1.01
The book at a glance
NEU-0.2%PRAX-1.3%DNTH+0.7%ACAD+4.1%SRRK+4.7%XENE+1.3%ARWR-1.1%ALKS-0.7%ARGX+0.3%BIIB+1.7%PTCT-0.1%DNLI-0.5%NBIX+0.0%AXSM-0.2%EWTX+0.0%DYN-0.5%SUPN+1.7%AXGN+2.7%SRPT-1.2%BHVN-6.0%TSHA+0.1%RAPP+0.9%IART-1.0%ANRO+0.4%LBRX+4.7%

CELL SIZE IS PORTFOLIO WEIGHT · COLOR IS TODAY’S MOVE · TOP 40 POSITIONS

HoldingsDownload CSV
#HoldingWeightPriceDay52-wk
1NEUNEWMARKET1.77%$950.10-0.2%
2PRAXPRAXIS PRECISION MEDICINES5.49%$371.07-1.3%
3DNTHMAGENTA THERAPEUTICS INC5.29%$115.50+0.7%
4ACADACADIA PHARMACEUTICALS4.85%$30.16+4.1%
5SRRKSCHOLAR ROCK HOLDING4.36%$54.53+4.7%
6XENEXENON PHARMACEUTICALS4.47%$63.13+1.3%
7ARWRARROWHEAD PHARMACEUTICALS4.50%$87.70-1.1%
8ALKSALKERMES4.32%$49.50-0.7%
9ARGXARGENX SE4.11%$993.93+0.3%
10BIIBBIOGEN3.97%$212.54+1.7%
11PTCTPTC THERAPEUTICS3.81%$72.69-0.1%
12DNLIDENALI THERAPEUTICS3.58%$24.21-0.5%
13NBIXNEUROCRINE BIOSCIENCES3.49%$154.20+0.0%
14AXSMAXSOME THERAPEUTICS3.45%$215.72-0.2%
15EWTXEDGEWISE THERAPEUTICS3.42%$43.99+0.0%

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Sector weights
Health Care99.08%
Information Technology0.76%
Cash and/or Derivatives0.14%
PORTFOLIO COMPOSITION, LATEST DISCLOSURE
Country weights
United States82.63%
Belgium4.11%
Korea (South)2.51%
Sweden2.19%
Switzerland1.96%
Australia1.77%
Denmark1.77%
China0.99%
PORTFOLIO COMPOSITION, LATEST DISCLOSURE
Performance
1 week+2.5%
1 month+7.1%
3 months+19.5%
6 months+28.4%
YTD+27.6%
1 year
3 years

PRICE RETURN, DISTRIBUTIONS NOT REINVESTED

Net flows
1 week−$24K
1 month+$2M
3 months+$2M
YTD+$2M
1 year+$2M

CREATION/REDEMPTION DOLLARS, DAILY RECORDS

Monthly net flows
AugSepOctNovDecJanFebMarAprMayJulAug
DAILY CREATION/REDEMPTION RECORDS, TRAILING TWELVE MONTHS
The risk read
22%realized volatility, 30 days (annualized)
26%realized volatility, 1 year
-9.1%deepest fall from a peak, 1 year
at peakwhere it sits vs. that peak today

The top holding is 5.5% of the book; the top ten carry 45%. Spread across 72+ names, it behaves like roughly 32 equally-weighted positions.

VOLATILITY & DRAWDOWN FROM THE DAILY TAPE · CONCENTRATION FROM THE LATEST DISCLOSED BOOK

Options tape
calls today
puts today
put/call ratio
945shares traded
Most-traded holdings, options premiumBullishBearish
ARGX ARGENX SE$1M$2M
BIIB BIOGEN$659,557$1M
CAPR CAPRICOR THERAPEUTICS$384,853$477,409
NMRA NEUMORA THERAPEUTICS INC$1,402$707,155
PRAX PRAXIS PRECISION MEDICINES$506,655$107,866

TODAY’S OPTIONS PREMIUM IN THE FUND’S UNDERLYING NAMES

The case against IBRN

Due diligence cuts both ways. These funds sit on the same shelf and beat IBRN on at least one dimension that matters — the fee, the asset base, or where the money is going.

FundFeeAssetsFlow, 1MThe case
IJH iShares Core S&P Mid-Cap ETF0.05%$128.4B+$547M-42bp on fee · +$547M in over the monthHead-to-head
IDEV iShares Core MSCI International Developed Markets ETF0.04%$32.7B+$104M-43bp on fee · +$104M in over the monthHead-to-head
IGSB iShares 1-5 Year Investment Grade Corporate Bond ETF0.04%$23.4B+$520M-43bp on fee · +$520M in over the monthHead-to-head
IGIB iShares 5-10 Year Investment Grade Corporate Bond ETF0.04%$18.7B+$312M-43bp on fee · +$312M in over the monthHead-to-head
IEFA iShares Core MSCI EAFE ETF0.07%$195.3B+$631M-40bp on fee · +$631M in over the monthHead-to-head
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InstrumentsHarvest substitutesTrade cost at $1MClient tearsheetStress this fund
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